Configured hotkeys must be unique and function globally across all applications, such as myPortal for Desktop, myPortal for Outlook, and myAgent. The first application to claim the hotkey will retain exclusive access; any subsequent applications attempting to use the same configured hotkey will fail to bind it. To prioritize a different application for the hotkey, restart all relevant applications, ensuring the preferred one starts first. Alternatively, close the conflicting application, reopen the setup, and click 'save' to refresh the hotkey services.